BMPR1A
BMPR1A (Bone Morphogenetic Protein Receptor Type 1A) is a protein that in humans is encoded by the BMPR1A gene. BMPR1A is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are involved in endochondral bone formation and embryogenesis.
Function[edit | edit source]
BMPR1A is a receptor for bone morphogenetic proteins (BMPs). It can be cleaved short by membrane-type matrix metalloproteinase 1 (MT1-MMP). This cleavage disrupts the ligand binding site of the extracellular domain of BMPR1A and leads to inactivation of BMP-dependent Smad signaling, thus promoting cell migration and invasion.
Clinical significance[edit | edit source]
Mutations in the BMPR1A gene are associated with juvenile polyposis syndrome, hereditary mixed polyposis syndrome, and Cowden disease, which are all inherited conditions associated with an increased risk of colorectal cancer.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- BMPR1A at the US National Library of Medicine Medical Subject Headings (MeSH)
BMPR1A Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD