BRENDA

BRENDA is a comprehensive enzyme information system that serves as a major resource for research in biochemistry, molecular biology, and biotechnology. It is managed by the Institute of Biochemistry, Biotechnology and Bioinformatics at the Technical University of Braunschweig in Germany.

Overview

BRENDA provides detailed information on enzyme functions, structures, and biochemical properties. It includes data on enzyme nomenclature, classification, kinetics, disease association, enzyme inhibitors, enzyme activators, and much more. The database is structured to facilitate both basic research and applied sciences in areas such as drug discovery and metabolic engineering.

Content and Features

The database contains a wide range of information on enzymes, including:

• Enzyme nomenclature and classification based on the recommendations of the International Union of Biochemistry and Molecular Biology (IUBMB)
• Kinetic properties of enzymes, such as KM and Vmax values
• Specific enzyme inhibitors and activators
• Information on enzyme-catalyzed reactions
• Metabolic pathways and their regulation
• Links to related genetic information
• Enzyme applications in biotechnology and medicine

Usage

BRENDA is widely used by scientists and researchers in the fields of biochemistry, pharmacology, medicine, and biotechnology. It serves as a critical tool for the identification of enzyme functions in metabolic pathways, the development of new drugs, and the design of enzymes for industrial applications.

Access

Access to BRENDA is provided through its website, where users can search for enzymes by various criteria, including EC number, enzyme name, organism, and more. The database also offers tools for the analysis of biochemical pathways and enzyme-related data.

Development and History

The development of BRENDA began in the early 1990s with the aim of providing a comprehensive enzyme database that is accessible to the scientific community worldwide. Over the years, it has evolved to include more detailed and diverse information, making it one of the most comprehensive enzyme databases available today.

See Also

• Enzyme
• Bioinformatics
• Metabolic pathway
• Drug discovery

External Links

Due to constraints, external links cannot be provided.