Barx homeobox 1

Barx homeobox 1 (also known as BARX1) is a protein that in humans is encoded by the BARX1 gene. This protein is a member of the BarH-like homeobox gene family, which plays a significant role in cellular differentiation and development.

Function

The BARX1 protein is a transcription factor that is involved in the development of the stomach and spleen. It is also associated with the formation of certain types of teeth. The protein is expressed in the mesenchyme of the developing stomach, spleen, and teeth, suggesting its role in the patterning and differentiation of these structures.

Clinical significance

Mutations in the BARX1 gene have been associated with congenital anomalies of the kidney and urinary tract (CAKUT). Additionally, variations in this gene are linked to an increased risk of gastroesophageal reflux disease (GERD) and esophageal cancer.

Genetics

The BARX1 gene is located on the long (q) arm of chromosome 9 at position 22.3, from base pair 96,276,507 to base pair 96,285,507.

See also

• Homeobox
• Transcription factor
• Congenital anomalies of the kidney and urinary tract
• Gastroesophageal reflux disease
• Esophageal cancer

External links

• BARX1 at the National Center for Biotechnology Information