Belnacasan
Belnacasan is a pharmaceutical drug that acts as an inhibitor of the caspase-1 enzyme. It is primarily used in the treatment of auto-inflammatory diseases and conditions characterized by excessive inflammation.
Mechanism of Action[edit | edit source]
Belnacasan works by inhibiting the activity of caspase-1, an enzyme that plays a crucial role in the inflammatory response. Caspase-1 is responsible for the activation of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). By inhibiting caspase-1, belnacasan reduces the production of these cytokines, thereby decreasing inflammation.
Clinical Uses[edit | edit source]
Belnacasan is used in the treatment of various auto-inflammatory diseases, including:
Side Effects[edit | edit source]
Common side effects of belnacasan include:
Research and Development[edit | edit source]
Belnacasan is currently under investigation for its potential use in treating other inflammatory conditions, such as rheumatoid arthritis and inflammatory bowel disease (IBD).
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
