Benzathine phenoxymethylpenicillin

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Benzathine phenoxymethylpenicillin is a penicillin-based antibiotic used in the treatment of various bacterial infections. It is a long-acting form of phenoxymethylpenicillin, and is often used in situations where prolonged antibiotic coverage is required.

Pharmacology[edit | edit source]

Benzathine phenoxymethylpenicillin is a prodrug that is slowly hydrolyzed after intramuscular injection, releasing phenoxymethylpenicillin. This slow release results in sustained blood levels of the antibiotic, allowing for less frequent dosing than with other penicillins. The drug is primarily bactericidal, and works by inhibiting bacterial cell wall synthesis.

Clinical Use[edit | edit source]

Benzathine phenoxymethylpenicillin is used in the treatment of a variety of infections caused by susceptible bacteria. These include streptococcal infections, syphilis, and rheumatic fever. It is also used as a prophylactic treatment to prevent recurrence of rheumatic fever and chorea.

Side Effects[edit | edit source]

As with all antibiotics, benzathine phenoxymethylpenicillin can cause side effects. These may include allergic reactions, gastrointestinal upset, and, rarely, anaphylaxis. Prolonged use can also lead to the development of antibiotic-resistant bacteria.

Contraindications[edit | edit source]

Benzathine phenoxymethylpenicillin should not be used in patients with a history of allergy to penicillins or cephalosporins. It should also be used with caution in patients with a history of gastrointestinal disease, particularly colitis.

See Also[edit | edit source]

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