Besifloxacin hydrochloride

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What is Besifloxacin hydrochloride?[edit | edit source]


Besifloxacin
Besifloxacin-3D-balls



What are the uses of this medicine?[edit | edit source]


How does this medicine work?[edit | edit source]

  • Besifloxacin is a fluoroquinolone antibacterial.
  • Besifloxacin is an 8-chloro fluoroquinolone with a N-1 cyclopropyl group.
  • The compound has activity against Gram-positive and Gram-negative bacteria due to the inhibition of both bacterial DNA gyrase and topoisomerase IV.
  • DNA gyrase is an essential enzyme required for replication, transcription and repair of bacterial DNA.
  • Topoisomerase IV is an essential enzyme required for partitioning of the chromosomal DNA during bacterial cell division.
  • Besifloxacin is bactericidal with minimum bactericidal concentrations (MBCs) generally within one dilution of the minimum inhibitory concentrations (MICs).


Who Should Not Use this medicine ?[edit | edit source]

  • This medicine have no usage limitations.


What drug interactions can this medicine cause?[edit | edit source]

  • No formal drug interaction studies have been conducted with Besivance.


Is this medicine FDA approved?[edit | edit source]

  • The eye drop was approved by the United States Food and Drug Administration (FDA) on May 29, 2009.


How should this medicine be used?[edit | edit source]

Recommended dosage:

  • Instill one drop in the affected eye(s) 3 times a day, four to twelve hours apart for 7 days.


Administration:

  • Patients should be advised to thoroughly wash hands prior to using Besivance.
  • Patients should be instructed to invert closed bottle (upside down) and shake once before each use. Remove cap with bottle still in the inverted position. Tilt head back, and with bottle inverted, gently squeeze bottle to instill one drop into the affected eye(s).
  • Patients should be advised not to wear contact lenses if they have signs or symptoms of bacterial conjunctivitis or during the course of therapy with Besivance™.


What are the dosage forms and brand names of this medicine?[edit | edit source]

This medicine is available in fallowing doasage form:

  • As 7.5 mL size bottle filled with 5 mL of besifloxacin ophthalmic suspension, 0.6%

This medicine is available in fallowing brand namesː

  • Besivance


What side effects can this medication cause?[edit | edit source]

The most common side effects of this medicine include:

  • conjunctival redness


What special precautions should I follow?[edit | edit source]

  • Besivance™ is for topical ophthalmic use only, and should not be injected subconjunctivally, nor should it be introduced directly into the anterior chamber of the eye.
  • As with other anti-infectives, prolonged use of Besivance™ (besifloxacin ophthalmic suspension) 0.6% may result in overgrowth of non-susceptible organisms, including fungi. If super-infection occurs, discontinue use and institute alternative therapy.
  • Patients should not wear contact lenses if they have signs or symptoms of bacterial conjunctivitis or during the course of therapy with Besivance.


What to do in case of emergency/overdose?[edit | edit source]

  • In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.


Can this medicine be used in pregnancy?[edit | edit source]

  • Since there are no adequate and well-controlled studies in pregnant women, Besivance™ should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Pregnancy Category C.


Can this medicine be used in children?[edit | edit source]

  • The safety and effectiveness of Besivance™ in infants below one year of age have not been established.


What are the active and inactive ingredients in this medicine?[edit | edit source]

Active ingredient:

  • BESIFLOXACIN

Inactive ingredients:

  • BENZALKONIUM CHLORIDE
  • POLYCARBOPHIL
  • MANNITOL
  • POLOXAMER 407
  • SODIUM CHLORIDE
  • EDETATE DISODIUM
  • SODIUM HYDROXIDE
  • WATER


Who manufactures and distributes this medicine?[edit | edit source]

Manufactured by:

  • Bausch & Lomb Incorporated
  • Tampa, Florida 33637
  • ©Bausch & Lomb Incorporated
  • Besivance™ is a trademark of Bausch & Lomb Incorporated


What should I know about storage and disposal of this medication?[edit | edit source]

  • Store at 15°- 25°C (59° - 77°F).
  • Protect from Light.
  • Invert closed bottle and shake once before use.


Besifloxacin hydrochloride Resources
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