Bitter

 proceeding from or exhibiting great hostility or animosity; expressive of severe grief or regret; one of the four basic taste sensations; sharp and disagreeable; like the taste of quinine; very difficult to accept or bear; marked by strong resentment or cynicism; causing a sharply painful or stinging sensation; used especially of cold; harsh or corrosive in tone; adv. extremely and sharply;  the taste experience when quinine or coffee is taken into the mouth; English term for a dry sharp-tasting ale with strong flavor of hops (usually on draft); the property of having a harsh unpleasant taste;  make bitter

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