Blood–saliva barrier

Blood–saliva barrier

The Blood–saliva barrier is a physiological partition that prevents certain components of the blood from entering saliva. It is a critical part of the salivary glands' function and plays a significant role in maintaining oral health.

Structure

The blood–saliva barrier is formed by the endothelial cells of the capillaries in the salivary glands and the epithelial cells of the salivary gland ducts. These cells are tightly packed together, forming a barrier that prevents certain substances from passing from the blood into the saliva.

Function

The primary function of the blood–saliva barrier is to regulate the composition of saliva. It allows certain substances, such as water, electrolytes, and certain proteins, to pass from the blood into the saliva. However, it prevents other substances, such as large proteins and certain drugs, from entering the saliva.

Clinical significance

The integrity of the blood–saliva barrier can be compromised by certain diseases and conditions, such as Sjögren's syndrome, HIV/AIDS, and certain types of cancer. When the barrier is compromised, substances that are normally excluded from the saliva can enter it, potentially leading to oral health problems.

See also

• Blood–brain barrier
• Blood–testis barrier
• Blood–ocular barrier