Bone morphogenetic protein 15
Bone morphogenetic protein 15 (also known as BMP15) is a protein that in humans is encoded by the BMP15 gene. BMP15 is a member of the transforming growth factor beta (TGFβ) superfamily, which is a group of proteins involved in the regulation of cellular processes.
Function[edit | edit source]
BMP15 is an oocyte-derived growth factor in ovarian follicles. It plays a key role in oocyte maturation, folliculogenesis, and female fertility. BMP15 is involved in the development of the ovarian follicle from the primary to the antral stage, and it also plays a role in the prevention of granulosa cell apoptosis.
Clinical significance[edit | edit source]
Mutations in the BMP15 gene have been associated with premature ovarian failure (POF), ovarian dysgenesis 1, and primary ovarian insufficiency (POI). These conditions are characterized by a loss of ovarian function before the age of 40.
Structure[edit | edit source]
The BMP15 protein is composed of 392 amino acids and has a molecular weight of approximately 44 kDa. It is synthesized as a preproprotein that undergoes proteolytic processing to generate the mature protein.
See also[edit | edit source]
References[edit | edit source]
 | This protein-related article is a stub. You can help WikiMD by expanding it. |
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
