Bottromycin

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Bottromycin A2

Bottromycin is a type of antibiotic that belongs to the class of ribosomally synthesized and post-translationally modified peptides (RiPPs). It was first discovered in the 1950s and is produced by certain strains of the bacterium Streptomyces. Bottromycin exhibits potent activity against a range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).

Structure and Biosynthesis

Bottromycin is characterized by its unique structure, which includes a macrocyclic peptide backbone and several unusual amino acids. The biosynthesis of bottromycin involves a series of enzymatic modifications that convert a precursor peptide into the mature antibiotic. These modifications include methylation, cyclization, and the formation of thiazole and oxazole rings.

Mechanism of Action

Bottromycin exerts its antibacterial effects by binding to the A-site of the ribosome, thereby inhibiting protein synthesis. This mechanism is distinct from other antibiotics, making bottromycin a valuable candidate for combating antibiotic-resistant bacteria.

Clinical Significance

Due to its effectiveness against resistant strains of bacteria, bottromycin is of significant interest in the field of medicine. Research is ongoing to develop bottromycin derivatives with improved pharmacological properties and to better understand its mechanism of action.

Related Pages

• Antibiotic
• Ribosome
• Streptomyces
• Methicillin-resistant Staphylococcus aureus
• Vancomycin-resistant Enterococci

External Links

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