Brodimoprim

Brodimoprim is a dihydrofolate reductase inhibitor that is used in the treatment of bacterial infections. It is a synthetic antibacterial agent that belongs to the pyrimidine class of antibiotics.

Mechanism of Action

Brodimoprim works by inhibiting the enzyme dihydrofolate reductase, which is necessary for the synthesis of tetrahydrofolate. Tetrahydrofolate is a critical component in the synthesis of purine and pyrimidine, which are essential for the production of DNA and RNA. By inhibiting this enzyme, Brodimoprim prevents the bacteria from synthesizing these vital components, thereby inhibiting their growth and reproduction.

Medical Uses

Brodimoprim is used in the treatment of various bacterial infections, including urinary tract infections, respiratory tract infections, and skin and soft tissue infections. It is often used in combination with other antibiotics to increase its effectiveness.

Side Effects

Like all medications, Brodimoprim can cause side effects. The most common side effects include nausea, vomiting, diarrhea, and rash. In rare cases, it can cause serious side effects such as anemia, leukopenia, and thrombocytopenia.

Contraindications

Brodimoprim is contraindicated in patients with a known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with severe renal impairment or liver disease, and in pregnant or breastfeeding women due to the potential risk to the fetus or infant.

Drug Interactions

Brodimoprim can interact with other medications, including other antibiotics, anticoagulants, and antiepileptic drugs. These interactions can alter the effectiveness of the drugs and increase the risk of side effects.

See Also

• Dihydrofolate reductase inhibitor
• Antibacterial
• Pyrimidine