Bromazepam

Bromazepam is a benzodiazepine derivative drug, patented by Roche in 1963 and developed clinically in the 1970s. It possesses anxiolytic, sedative, hypnotic, anticonvulsant, muscle relaxant and amnesic properties. Bromazepam is most commonly used as a short-term treatment for anxiety disorders and panic attacks.

Pharmacology

Bromazepam binds to the GABA_A receptor, causing a conformational change and increasing inhibitory effects of GABA. Further, bromazepam may inhibit voltage dependent sodium channels to a lesser extent. The half-life of bromazepam is 12-20 hours.

Medical uses

Bromazepam is indicated for the short-term treatment of insomnia, short-term treatment of anxiety or panic attacks, if a benzodiazepine is required, and the alleviation of the symptoms of alcohol- and drug-withdrawal.

Side effects

Common side effects of bromazepam are similar to those of other benzodiazepines and can include drowsiness, fatigue, light-headedness, and dry mouth. Less common side effects can include dysphoria, changes in libido, and muscle weakness.

Interactions

Bromazepam can interact with a number of medications, including other CNS depressants, certain antidepressants, and certain antibiotics. It is important to consult with a healthcare provider before starting or stopping any medications.

See also

• Benzodiazepine
• GABA_A receptor
• Anxiety disorder
• Insomnia

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