Bromsulphthalein
| Bromsulphthalein_structure.png Chemical structure of Bromsulphthalein | |
Bromsulphthalein (BSP) is a synthetic dye used primarily in the Bromsulphthalein test, a diagnostic procedure to assess liver function. It is a sulfonphthalein compound that is excreted by the liver, and its retention in the bloodstream can indicate hepatic dysfunction.
History[edit | edit source]
Bromsulphthalein was first introduced in the early 20th century as a tool for evaluating liver function. It gained popularity due to its ability to provide quantitative data on liver excretory capacity. However, with the advent of more advanced diagnostic techniques, its use has declined.
Chemical Properties[edit | edit source]
Bromsulphthalein is a brominated derivative of phenolphthalein. It is a large, complex molecule with the chemical formula C20H10Br4O10S2. The presence of bromine atoms contributes to its high molecular weight and its distinctive color, which is useful in its application as a dye.
Mechanism of Action[edit | edit source]
Bromsulphthalein is administered intravenously and is rapidly taken up by the liver. It is conjugated with glutathione and excreted into the bile. The rate of clearance from the bloodstream is used to assess liver function. In cases of liver disease, the excretion of BSP is impaired, leading to higher levels remaining in the blood.
Clinical Use[edit | edit source]
The Bromsulphthalein test involves measuring the concentration of BSP in the blood at specific intervals after administration. A delayed clearance indicates potential liver dysfunction. Although it was once a standard test, it has largely been replaced by more modern methods such as liver function tests that measure serum enzyme levels.
Safety and Side Effects[edit | edit source]
Bromsulphthalein is generally safe when used in diagnostic doses. However, it can cause allergic reactions in some individuals. Care should be taken in patients with known hypersensitivity to sulfonphthalein compounds.
Current Status[edit | edit source]
While the use of Bromsulphthalein has decreased, it remains a part of the historical development of liver function testing. It is occasionally used in research settings to study hepatic excretory function.
Also see[edit | edit source]
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