Bucladesine

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Bucladesine (also known as dibutyryl cyclic AMP, dbcAMP) is a cell-permeable cyclic AMP (cAMP) analog. It is used in research due to its ability to mimic the action of cAMP, a second messenger in cells that is involved in a wide range of physiological processes.

Structure and Properties[edit | edit source]

Bucladesine is a derivative of adenosine monophosphate (AMP) in which the phosphate group is replaced by a butyryl group. This modification makes the molecule more lipophilic, allowing it to easily cross cell membranes. The cyclic structure of bucladesine is similar to that of cAMP, enabling it to bind to and activate the same intracellular targets.

Mechanism of Action[edit | edit source]

Bucladesine acts as a cAMP analog by binding to and activating protein kinase A (PKA), a key enzyme in the cAMP signaling pathway. PKA phosphorylates a variety of target proteins, leading to changes in cell function. By mimicking the action of cAMP, bucladesine can induce these changes even in the absence of the natural signal.

Applications in Research[edit | edit source]

Bucladesine is widely used in biological research to study the effects of cAMP signaling. It can be used to activate PKA in cells, allowing researchers to investigate the roles of this enzyme in various processes. For example, it has been used to study the role of cAMP in regulating gene expression, cell proliferation, and apoptosis.

Safety and Toxicity[edit | edit source]

As a research chemical, bucladesine is not intended for human consumption. It should be handled with care to avoid exposure. The safety and toxicity of bucladesine in humans have not been fully studied.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD