C-Fos

C-Fos is a protein that, in humans, is encoded by the c-fos gene. It is a member of the AP-1 transcription factor family, which plays a role in cell proliferation, differentiation, and transformation. C-Fos forms a dimer with other proteins, such as c-Jun, to form the AP-1 complex that binds to DNA and regulates gene expression.

Function

C-Fos is a nuclear protein that functions as a transcription factor. It is rapidly and transiently induced by a variety of extracellular stimuli, including growth factors, cytokines, and neuronal activity. The protein is involved in several cellular processes, including cell proliferation, differentiation, apoptosis, and oncogenic transformation.

Structure

The c-Fos protein is composed of several domains, including a basic leucine zipper domain (bZIP) that is involved in dimerization and DNA binding, and a transactivation domain that is responsible for the transcriptional activity of the protein.

Clinical significance

Alterations in the expression of the c-fos gene have been associated with several human cancers, including osteosarcoma, lung cancer, and breast cancer. In addition, c-Fos has been implicated in a number of neurological disorders, such as Alzheimer's disease and Parkinson's disease.

See also

• FosB
• c-Jun
• AP-1 transcription factor
• Oncogene

References

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