CBX3

CBX3 or Chromobox 3 is a protein that in humans is encoded by the CBX3 gene. It is a member of the heterochromatin protein 1 (HP1) family, which is involved in chromosome structure and gene expression.

Function

CBX3 is a non-histone chromosome protein that binds to heterochromatin and is thought to play a role in maintaining chromatin structure and gene silencing. It contains a chromodomain at the N-terminus and a chromo shadow-domain at the C-terminus, which allows it to interact with other proteins and RNA.

Clinical Significance

Alterations in the expression of CBX3 have been associated with several types of cancer, including breast cancer, prostate cancer, and lung cancer. It has been suggested that CBX3 may serve as a potential biomarker for these diseases.

Research

Research into the function and potential therapeutic applications of CBX3 is ongoing. It is thought that understanding the role of CBX3 in cellular processes and disease may lead to the development of new treatments for cancer and other diseases.

See Also

• Chromobox
• Heterochromatin protein 1
• Gene expression
• Chromodomain