CD147
CD147 (Cluster of Differentiation 147), also known as EMMPRIN (Extracellular Matrix Metalloproteinase Inducer) or Basigin (BSG), is a transmembrane protein that is a member of the immunoglobulin superfamily. It is widely expressed in various cell types including tumor cells, blood cells, and endothelial cells. CD147 plays a crucial role in many physiological and pathological processes, including spermatogenesis, embryo implantation, tumor invasion, and metastasis.
Function[edit | edit source]
CD147 has a diverse range of functions in the body. It is involved in the regulation of matrix metalloproteinases (MMPs), which are enzymes responsible for the degradation of the extracellular matrix (ECM). This regulation is crucial for processes such as cell migration, tissue remodeling, and angiogenesis. In addition to its role in MMP regulation, CD147 is also involved in sperm-egg fusion during fertilization, energy metabolism by facilitating the transport of monocarboxylates across cell membranes, and immune response modulation.
Clinical Significance[edit | edit source]
The expression of CD147 is significantly upregulated in various cancers, making it a potential target for cancer therapy. Its role in inducing MMPs contributes to tumor progression by promoting invasion and metastasis. Furthermore, CD147 is involved in the resistance of cancer cells to chemotherapy and radiotherapy, highlighting its potential as a therapeutic target.
In addition to cancer, CD147 has been implicated in other diseases such as rheumatoid arthritis, where it is involved in the inflammation process, and cardiovascular diseases, through its role in angiogenesis and atherosclerosis.
Research and Therapeutic Approaches[edit | edit source]
Given its involvement in several critical biological processes and diseases, CD147 is a target for therapeutic intervention. Research is ongoing to develop antibodies, small molecule inhibitors, and vaccines targeting CD147 for the treatment of cancer and other diseases. One example is the development of anti-CD147 monoclonal antibodies, which have shown promise in reducing tumor growth and metastasis in preclinical models.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
