CD16
CD16 is a protein that in humans is encoded by the FCGR3A gene. It is a low affinity receptor for the Fc region of immunoglobulin G (IgG) and is involved in immune response and immune system processes.
Structure[edit | edit source]
CD16 exists in two forms - CD16a and CD16b. CD16a is a transmembrane protein found on the surface of natural killer cells, macrophages, and neutrophils. CD16b is a glycosylphosphatidylinositol (GPI)-anchored protein present on neutrophils.
Function[edit | edit source]
CD16 plays a crucial role in the immune response, including antibody-dependent cell-mediated cytotoxicity (ADCC). It binds to the Fc portion of IgG antibodies which then induces phagocytosis by macrophages, and cytotoxicity mediated by natural killer cells.
Clinical significance[edit | edit source]
Alterations in the CD16 gene have been associated with susceptibility to rheumatoid arthritis, systemic lupus erythematosus, and transplant rejection.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- CD16 at UniProt
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Contributors: Prab R. Tumpati, MD
