CD18

CD18 is a protein that in humans is encoded by the ITGB2 gene. It is also known as integrin beta chain-2. CD18 is a cluster of differentiation molecule found on white blood cells, which are crucial components of the immune system.

Function

CD18, in conjunction with CD11a, CD11b, and CD11c, forms leukocyte integrins, which are proteins that enable leukocytes to adhere to the endothelium. This adhesion is a critical step in the process of leukocyte extravasation, which allows leukocytes to exit the bloodstream and enter tissues where they can combat infection.

Clinical significance

Mutations in the ITGB2 gene can lead to a condition known as Leukocyte adhesion deficiency (LAD). LAD is characterized by recurrent bacterial infections, impaired wound healing, and delayed umbilical cord separation. There are three types of LAD, with LAD-I being the most common and resulting from a deficiency in CD18.

See also

• Cluster of differentiation
• Leukocyte adhesion deficiency
• Integrin

References

CD18 Resources
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