CD18
CD18 is a protein that in humans is encoded by the ITGB2 gene. It is also known as integrin beta chain-2. CD18 is a cluster of differentiation molecule found on white blood cells, which are crucial components of the immune system.
Function[edit | edit source]
CD18, in conjunction with CD11a, CD11b, and CD11c, forms leukocyte integrins, which are proteins that enable leukocytes to adhere to the endothelium. This adhesion is a critical step in the process of leukocyte extravasation, which allows leukocytes to exit the bloodstream and enter tissues where they can combat infection.
Clinical significance[edit | edit source]
Mutations in the ITGB2 gene can lead to a condition known as Leukocyte adhesion deficiency (LAD). LAD is characterized by recurrent bacterial infections, impaired wound healing, and delayed umbilical cord separation. There are three types of LAD, with LAD-I being the most common and resulting from a deficiency in CD18.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
