CD30+ cutaneous T-cell lymphoma

CD30+ cutaneous T-cell lymphoma (CTCL) is a subtype of cutaneous T-cell lymphoma, a group of non-Hodgkin lymphomas that primarily affect the skin. CD30+ CTCL is characterized by the presence of CD30 protein on the surface of the malignant T-cells.

Epidemiology

CD30+ CTCL is a rare disease, accounting for approximately 10% of all CTCL cases. It is more common in adults, with a median age of diagnosis in the fifth decade of life. There is a slight male predominance.

Pathogenesis

The pathogenesis of CD30+ CTCL is not fully understood. It is believed to be caused by the transformation of mature T-cells that express the CD30 protein. The exact trigger for this transformation is unknown, but it is thought to involve genetic and environmental factors.

Clinical Features

Patients with CD30+ CTCL typically present with skin lesions that can vary in appearance. These may include patches, plaques, tumors, or ulcerated lesions. The lesions are often red or purple and may be itchy. In some cases, the disease can spread to the lymph nodes or other organs.

Diagnosis

The diagnosis of CD30+ CTCL is based on the clinical presentation, histopathological examination of a skin biopsy, and immunohistochemical staining for the CD30 protein. Other tests, such as blood tests and imaging studies, may be performed to assess the extent of the disease.

Treatment

The treatment of CD30+ CTCL depends on the stage of the disease. Early-stage disease is typically treated with skin-directed therapies, such as topical corticosteroids, phototherapy, or radiation therapy. For advanced-stage disease, systemic therapies, including chemotherapy and immunotherapy, may be used.

Prognosis

The prognosis of CD30+ CTCL is generally favorable, especially for patients with localized disease. However, the disease can be recurrent and may require long-term management.

See Also

• Cutaneous T-cell lymphoma
• Non-Hodgkin lymphoma
• T-cells
• CD30