CD49b

CD49b is a protein that in humans is encoded by the ITGA2 gene. It is also known as Integrin alpha-2 or VLA-2 subunit alpha. This protein is a member of the integrin family and when paired with the beta chain CD29, forms a receptor for laminin and collagen. It is expressed in platelets and several cell types on the vascular endothelium. The protein takes part in adhesion as well as cell-surface mediated signalling.

Structure

The CD49b protein is a type of integrin alpha chain proteins. These proteins are generally linked to a beta chain, forming a heterodimeric, non-covalent complex. In the case of CD49b, it is usually associated with the beta chain CD29. The alpha chain contains the I-domain, which is involved in ligand binding.

Function

CD49b plays a crucial role in the immune system. It is involved in a variety of cellular activities including cell adhesion, cell migration, and cellular signaling. It is also involved in the process of platelet activation and aggregation, and in the process of leukocyte migration.

Clinical significance

Alterations in the normal function or levels of CD49b have been associated with a variety of diseases. For example, increased levels of CD49b have been observed in patients with rheumatoid arthritis and systemic lupus erythematosus. It has also been implicated in certain types of cancer, including breast cancer and colorectal cancer.

See also

• Integrin
• ITGA2
• CD29

References

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