CD71

CD71, also known as transferrin receptor protein 1 (TfR1), is a protein that in humans is encoded by the TFRC gene. It is a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. CD71 is required for cell division and is expressed in all dividing cells.

Structure

CD71 is a type II transmembrane glycoprotein. It is composed of two identical subunits, each of which has an extracellular domain, a transmembrane domain, and a short cytoplasmic tail. The extracellular portion of CD71 is composed of three domains: a protease-like domain, an apical domain, and a helical domain. The cytoplasmic tail of CD71 contains a YXXØ motif, which is necessary for its internalization.

Function

CD71 is a carrier for regulated iron delivery in every cell. It plays a crucial role in the control of cell growth and cell differentiation. The receptor is regulated by the cellular iron concentration and by the iron-binding protein transferrin.

Clinical significance

CD71 is overexpressed in a variety of cancers, including breast cancer, ovarian cancer, colon cancer, and lung cancer. It is also a marker for erythroid progenitor cells, activated lymphocytes, and can be used as a target for selective drug delivery.

See also

• Transferrin receptor
• Iron metabolism
• Transferrin

References

CD71 Resources
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