CDC26

CDC26 is a protein that in humans is encoded by the CDC26 gene. The CDC26 protein is a component of the anaphase-promoting complex (APC), which is a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

Function

The anaphase-promoting complex (APC) is a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC complex is composed of several proteins, one of which is CDC26. The APC complex is responsible for the ubiquitination and subsequent degradation of specific target proteins, which is a key mechanism in the control of cell cycle progression.

Clinical significance

Mutations in the CDC26 gene have been associated with various types of cancer, including breast cancer, colorectal cancer, and lung cancer. The exact role of CDC26 in cancer development and progression is still under investigation, but it is thought to be involved in the regulation of cell proliferation and apoptosis.

See also

• Anaphase-promoting complex
• Cell cycle
• Ubiquitin-proteasome system