CELSR2

CELSR2 (Cadherin EGF LAG seven-pass G-type receptor 2) is a protein that in humans is encoded by the CELSR2 gene. This protein is a member of the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion.

Function

The CELSR2 protein plays a crucial role in the establishment of planar cell polarity, especially in the mammalian nervous system. Planar cell polarity refers to the coordinated orientation of cells within the plane of a tissue or organ. CELSR2 is involved in various cellular processes including cell adhesion, cell migration, neurogenesis, and the establishment of tissue morphology.

Structure

The CELSR2 protein is a type of Flamingo protein, characterized by a large extracellular domain with multiple epidermal growth factor (EGF)-like repeats and a seven-pass transmembrane domain, similar to that seen in G-protein coupled receptors.

Clinical significance

Mutations in the CELSR2 gene have been associated with various medical conditions. For instance, a genetic variant in the CELSR2 gene has been linked to a decreased risk of coronary artery disease. Further research is needed to fully understand the role of CELSR2 in human health and disease.

See also

• Cadherin
• Planar cell polarity
• Coronary artery disease

References

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