Epidermal growth factor

From WikiMD's Wellnesspedia

Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. EGF was originally discovered in the submaxillary glands of mice and in human urine. EGF has since been found in many human tissues including submandibular gland and parotid gland.

Function[edit | edit source]

The main function of EGF is to stimulate the growth of epithelial and epidermal cells in vivo and in vitro. It also has a role in wound healing, and it can stimulate the proliferation of fibroblasts, which are involved in tissue repair.

Structure[edit | edit source]

EGF is a small protein with a molecular weight of about 6 kDa. It is composed of 53 amino acid residues and contains three intramolecular disulfide bonds.

Clinical significance[edit | edit source]

EGF has been used in the treatment of chronic wounds or ulcers, such as diabetic foot ulcers. It can also be used in the treatment of certain types of cancer, as it can stimulate the growth of cancer cells.

See also[edit | edit source]

References[edit | edit source]


Epidermal growth factor Resources

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Contributors: Bonnu, Prab R. Tumpati, MD