CETP

CETP or Cholesteryl ester transfer protein is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very-low-density lipoproteins (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa.

Function

CETP is secreted by the liver and circulates in the blood where it binds to lipoproteins. Its main function is to transport cholesteryl esters from HDL to VLDL and LDL. This process is known as the reverse cholesterol transport pathway, which is a mechanism that removes cholesterol from tissues and delivers it to the liver for excretion.

Clinical significance

Alterations in the function of CETP have been linked to disorders of lipoprotein metabolism and the development of atherosclerosis. Inhibition of CETP activity raises HDL cholesterol levels and has been suggested as a strategy to reduce the risk of coronary artery disease. However, the clinical benefits of CETP inhibitors are still under investigation.

Genetics

The CETP gene is located on the long arm of chromosome 16 (16q21). Polymorphisms in this gene are associated with variations in HDL and LDL cholesterol levels, and may influence the risk of cardiovascular disease.

See also

• Lipoprotein
• Atherosclerosis
• Coronary artery disease

References

CETP Resources
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