CIZ1

CIZ1 is a protein that in humans is encoded by the CIZ1 gene. It is a DNA-binding protein that specifically binds to the consensus sequence 5'-D(G/T)(A/T)G-3'. CIZ1 is known to play a crucial role in cell cycle regulation and DNA replication.

Function

CIZ1 is a nuclear matrix protein that plays a role in the initiation of DNA replication. It is a member of the zinc finger protein family and has 12 C2H2-type zinc fingers. CIZ1 interacts with p21, a regulator of the cell cycle, and it is thought to enhance the cell cycle progression from G1 to S phase.

Clinical significance

Mutations in the CIZ1 gene have been associated with adult onset primary cervical dystonia, a type of movement disorder. Studies have also shown that CIZ1 may be a potential biomarker for lung cancer and other neoplasms.

Further research

Further research is being conducted to understand the role of CIZ1 in neurodegenerative diseases and its potential as a therapeutic target.

See also

• Zinc finger
• DNA-binding protein
• Cell cycle
• Dystonia
• Biomarker

References

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