CNOT4

CNOT4 (CCR4-NOT transcription complex subunit 4) is a protein that in humans is encoded by the CNOT4 gene. This protein is a component of the CCR4-NOT complex, a regulator of mRNA synthesis and degradation. It has been implicated in a variety of biological processes including cell cycle control, apoptosis, and the immune response.

Function

CNOT4 is a component of the CCR4-NOT complex which contributes to the regulation of mRNA synthesis and degradation. It is involved in various cellular processes such as cell cycle control, apoptosis, and the immune response. CNOT4 has E3 ubiquitin-protein ligase activity, which means it can attach ubiquitin to target proteins, marking them for degradation by the proteasome. This process is known as ubiquitination.

Structure

The CNOT4 protein is composed of 485 amino acids and has a molecular weight of approximately 54 kDa. It contains a RING-type zinc finger domain, which is involved in protein-protein interactions and is necessary for its E3 ubiquitin-protein ligase activity.

Clinical significance

Mutations in the CNOT4 gene have been associated with various diseases. For example, a mutation in this gene has been linked to autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Further research is needed to fully understand the role of CNOT4 in disease development and progression.

See also

• CCR4-NOT
• Ubiquitination
• Proteasome
• Zinc finger

References

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