CP-286601

A detailed overview of the compound CP-286601

CP-286601 is a chemical compound that has been studied for its potential effects on the central nervous system. It is primarily known for its role as a selective antagonist of the 5-HT2C receptor, which is a subtype of the serotonin receptor family. This compound has been of interest in research related to psychiatric and neurological disorders.

Chemical Structure and Properties

CP-286601 is classified as a piperazine derivative. Its chemical structure consists of a piperazine ring bonded to an indole moiety and a dihydroindene group. The molecular formula of CP-286601 is C₁₈H₂₀N₂, and it has a molecular weight of 318.46 g/mol.

Pharmacology

CP-286601 acts as a selective antagonist at the 5-HT2C receptor. The 5-HT2C receptor is one of the several subtypes of serotonin receptors, which are involved in the modulation of neurotransmission in the brain. By blocking this receptor, CP-286601 can influence various physiological and psychological processes, including mood, anxiety, and appetite regulation.

Mechanism of Action

The mechanism by which CP-286601 exerts its effects involves the inhibition of serotonin binding to the 5-HT2C receptor. This receptor is a G protein-coupled receptor (GPCR) that, when activated by serotonin, can influence intracellular signaling pathways. By antagonizing this receptor, CP-286601 may alter the downstream effects of serotonin signaling, potentially leading to changes in mood and behavior.

Research and Potential Applications

Research on CP-286601 has primarily focused on its potential therapeutic applications in treating disorders such as depression, anxiety, and obesity. The compound's ability to modulate serotonin signaling makes it a candidate for further investigation in these areas.

Preclinical Studies

In preclinical studies, CP-286601 has been shown to affect feeding behavior and body weight in animal models, suggesting its potential use in the treatment of obesity. Additionally, its effects on mood regulation have been explored in the context of depression and anxiety models.

Safety and Toxicology

As with any investigational compound, the safety and toxicological profile of CP-286601 is an important consideration. Studies have been conducted to assess its potential side effects and toxicity in animal models, but comprehensive human safety data are not yet available.

Also see

• Serotonin receptor
• 5-HT2C receptor
• Piperazine
• Neurotransmitter
• Psychopharmacology

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