CRYL1

CRYL1 is a gene that encodes the enzyme crystallin, lambda 1 in humans. This enzyme is part of the aldehyde dehydrogenase family, which is involved in the metabolic process of converting aldehydes to their corresponding acids.

Function

The CRYL1 gene is responsible for the production of the crystallin, lambda 1 enzyme. This enzyme is primarily found in the liver and kidney, and plays a crucial role in the metabolism of certain aldehydes. It is also involved in the urea cycle, which is the metabolic pathway that produces urea from ammonia. This process is essential for the removal of excess ammonia from the body.

Clinical significance

Mutations in the CRYL1 gene have been associated with various health conditions. For instance, a study found that a specific mutation in this gene was linked to non-syndromic intellectual disability. This suggests that the CRYL1 gene plays a role in brain development and function.

Furthermore, the CRYL1 gene has been implicated in cancer. Research has shown that the expression of this gene is significantly altered in certain types of cancer, including hepatocellular carcinoma and renal cell carcinoma. This indicates that the CRYL1 gene may be involved in the development and progression of these cancers.

See also

• Aldehyde dehydrogenase
• Urea cycle
• Non-syndromic intellectual disability
• Hepatocellular carcinoma
• Renal cell carcinoma