CXCR1

CXCR1 (C-X-C chemokine receptor type 1) is a protein that in humans is encoded by the CXCR1 gene. It is a G protein-coupled receptor that binds to interleukin 8 (IL-8) and is involved in the immune response.

Structure

CXCR1 is a member of the chemokine receptor family, which are seven-transmembrane domain receptors. These receptors are characterized by their ability to traverse the cell membrane seven times. The structure of CXCR1 allows it to interact with its ligand, IL-8, and initiate a signaling cascade inside the cell.

Function

The primary function of CXCR1 is to mediate the chemotaxis of neutrophils to sites of inflammation. Upon binding to IL-8, CXCR1 activates intracellular signaling pathways that result in the directed movement of neutrophils. This process is crucial for the body's immune defense against infection and tissue damage.

Clinical significance

CXCR1 has been implicated in various disease processes, including cancer, inflammatory diseases, and autoimmune disorders. Overexpression of CXCR1 has been observed in certain types of breast cancer, where it may contribute to tumor progression and metastasis.

See also

• Chemokine receptor
• Interleukin 8
• G protein-coupled receptor

External links

• Template:PBB
• CXCR1 on WikiMD