CYP4F11

CYP4F11 is a member of the cytochrome P450 superfamily of enzymes. These enzymes are monooxygenases which catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids. The CYP4F11 gene is located on chromosome 19 in humans.

Function

CYP4F11 is involved in the metabolism of various endogenous and exogenous compounds. It is known to hydroxylate long-chain fatty acids and is involved in the metabolism of arachidonic acid and eicosanoids. This enzyme plays a role in the inactivation of leukotriene B4, a potent inflammatory mediator.

Expression

CYP4F11 is expressed in various tissues, including the liver, kidney, lung, and skin. Its expression can be influenced by various factors, including cytokines, growth factors, and xenobiotics.

Clinical Significance

Alterations in the expression or function of CYP4F11 can have implications for drug metabolism and the development of certain diseases. For example, variations in the CYP4F11 gene may affect the metabolism of therapeutic drugs, potentially leading to altered drug efficacy or adverse drug reactions.

Related Cytochrome P450 Enzymes

CYP4F11 is part of the CYP4F subfamily, which includes other enzymes such as CYP4F2, CYP4F3, and CYP4F12. These enzymes share similar functions and are involved in the metabolism of fatty acids and eicosanoids.

See Also

• Cytochrome P450
• Drug metabolism
• Arachidonic acid
• Eicosanoids
• Leukotriene B4