CYP4F2

• CYP4F2 is a member of the cytochrome P450 enzyme family involved in the metabolism of various endogenous compounds and exogenous substances.
• This enzyme is primarily expressed in the liver and is encoded by the CYP4F2 gene.
• CYP4F2 plays a role in the metabolism of fatty acids, eicosanoids, and xenobiotics.

Functions of CYP4F2 =

• The main functions of CYP4F2 include:

Fatty Acid Metabolism:

• CYP4F2 participates in the metabolism of long-chain fatty acids, including omega-3 and omega-6 fatty acids.
• It is involved in the oxidation of these fatty acids, contributing to their breakdown and subsequent elimination from the body.

Eicosanoid Metabolism:

• Eicosanoids are signaling molecules derived from arachidonic acid and play important roles in inflammation and blood clotting.
• CYP4F2 contributes to the metabolism of certain eicosanoids, such as leukotrienes and prostaglandins, through oxidation reactions.
• This metabolism helps regulate the levels and activities of these signaling molecules in the body.

Xenobiotic Metabolism:

• CYP4F2 participates in the metabolism of various xenobiotics, including drugs and environmental chemicals.
• It can metabolize certain medications and xenobiotics through oxidation reactions, leading to their inactivation or conversion into more polar forms for elimination.

Genetic Variations

• Genetic variations in the CYP4F2 gene can influence enzyme activity and individual responses to certain medications.

• Some notable genetic variants include:

CYP4F2*3 (rs2108622):

• This variant is associated with reduced enzyme activity compared to the wild-type allele.
• Individuals carrying the CYP4F2*3 variant may exhibit altered drug metabolism and responses to certain medications.

Clinical Significance

• The CYP4F2*3 variant has been particularly studied in relation to its impact on medication response, including:
• Warfarin: CYP4F2 is involved in the metabolism of warfarin, an anticoagulant medication. Individuals carrying the CYP4F2*3 variant may exhibit altered warfarin metabolism, potentially requiring adjusted dosage regimens and closer monitoring of anticoagulation levels.

• It's important to note that the impact of CYP4F2 genetic variations on drug metabolism and therapeutic outcomes may vary depending on the specific medication, other genetic factors, and individual patient characteristics. Pharmacogenetic testing may be considered in certain clinical scenarios to guide personalized medication selection and dosing.

Alternate Names:

• CYP4F2, also known as Cytochrome P450 4F2, is an enzyme encoded by the CYP4F2 gene.

While it is primarily recognized by its official name, CYP4F2, this gene and its corresponding enzyme are known by other names as well:

• Leukotriene B4 omega-hydroxylase: CYP4F2 gained attention as the primary enzyme responsible for the omega-hydroxylation of leukotriene B4, an important eicosanoid involved in inflammation and immune responses.

• Lipoxin A4 omega-hydroxylase: CYP4F2 also participates in the omega-hydroxylation of lipoxin A4, a specialized pro-resolving mediator derived from arachidonic acid that plays a role in the resolution of inflammation.

• Arachidonic acid monooxygenase: CYP4F2 is involved in the oxidation of arachidonic acid, a polyunsaturated fatty acid that serves as a precursor for various eicosanoids.

• These alternative names may be encountered in scientific literature or discussions related to CYP4F2.

See Also

• Cytochrome P450 Enzymes
• Pharmacogenetics
• Drug Metabolism
• Pharmacokinetics

CYP4F2 Resources
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