Carbetocin
Carbetocin is a synthetic oxytocin analogue. It is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth, particularly following Caesarean section.
Pharmacology[edit | edit source]
Carbetocin primarily acts on the oxytocin receptor, a G-protein coupled receptor, in the uterus. It stimulates the smooth muscle tissue of the uterus, causing contractions. This helps to reduce bleeding after childbirth.
Medical uses[edit | edit source]
Carbetocin is used to prevent excessive bleeding after childbirth, a condition known as postpartum hemorrhage. It is particularly useful following Caesarean section, where the risk of postpartum hemorrhage is higher.
Side effects[edit | edit source]
Common side effects of carbetocin include nausea, vomiting, abdominal pain, flushing, and itching. In rare cases, it can cause severe allergic reactions.
Contraindications[edit | edit source]
Carbetocin should not be used in patients with hypersensitivity to the drug or any of its components. It is also contraindicated in patients with significant cardiovascular disease due to the risk of tachycardia and hypertension.
History[edit | edit source]
Carbetocin was first synthesized in the 1980s and has been used in clinical practice since the early 1990s. It is currently available in over 90 countries worldwide.
See also[edit | edit source]
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