Carbon monoxide-releasing molecules
Carbon monoxide-releasing molecules (CORMs) are a group of chemical compounds that release carbon monoxide (CO) in a controlled manner. They are a subject of research due to their potential therapeutic applications, particularly in the field of pharmacology and medicine.
Overview[edit | edit source]
CORMs are designed to deliver carbon monoxide to biological systems. Carbon monoxide, a gaseous molecule, has been recognized for its potential therapeutic effects, including anti-inflammatory, anti-apoptotic, and anti-proliferative activities. However, due to its toxic nature, direct administration of CO is not feasible. CORMs, therefore, provide a safer and more effective way to deliver CO.
Types of CORMs[edit | edit source]
There are several types of CORMs, classified based on their chemical structure and CO release mechanism. These include:
- Metal carbonyls: These are the most extensively studied CORMs. Examples include CORM-2 (ruthenium carbonyl) and CORM-3 (tricarbonylchloro(glycinato)ruthenium(II)).
- Boron-based CORMs: These are non-metal based CORMs that release CO upon reaction with a specific trigger, such as light or a particular enzyme.
- PhotoCORMs: These CORMs release CO upon exposure to light.
Therapeutic Applications[edit | edit source]
CORMs have potential therapeutic applications in various medical conditions, including:
- Cardiovascular diseases: CORMs have been shown to reduce myocardial infarction size and improve heart function in animal models.
- Inflammatory diseases: CORMs exhibit anti-inflammatory effects and may be beneficial in conditions such as rheumatoid arthritis and inflammatory bowel disease.
- Cancer: CORMs have anti-proliferative effects and may inhibit tumor growth.
Safety and Toxicity[edit | edit source]
While CORMs provide a safer way to deliver CO, their safety and toxicity profile is still a subject of research. Factors such as the rate of CO release, the stability of the CORM, and the presence of other toxic by-products can influence their safety and efficacy.
See Also[edit | edit source]
References[edit | edit source]
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