Reperfusion injury

Reperfusion Injury

Illustration of myocardial reperfusion, a common type of reperfusion injury.

Reperfusion Injury refers to the paradoxical tissue damage caused when blood supply returns to tissue (reperfusion) after a period of ischemia (lack of oxygen). This condition is characterized by functional, metabolic, or structural changes in the ischemic tissues.

Pathophysiology

Reperfusion injury involves complex biological reactions including:

• Cellular swelling and inflammation
• Hemorrhage
• Necrosis (tissue death)
• Oxidative stress from free radicals, which can further damage cells

Common Instances

The most prevalent instance of reperfusion injury is:

• Myocardial reperfusion injury: Occurs when blood flow is restored to the heart after a heart attack.

Complications

Complications of reperfusion injury can significantly impact recovery and overall outcomes, particularly in acute myocardial infarction and stroke.

Treatment and Management

Medical intervention for managing reperfusion injury.

Treatment focuses on minimizing tissue damage and may include:

• Controlled reperfusion strategies
• Use of antioxidants and other drugs to mitigate oxidative stress
• Surgical interventions in severe cases

External Links

• American Heart Association - Myocardial Reperfusion Injury
• National Center for Biotechnology Information - Reperfusion Injury

Reperfusion injury Resources
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