Carboxyphosphamide

Carboxyphosphamide is a pharmacological agent that belongs to the class of drugs known as alkylating agents. It is a derivative of cyclophosphamide, a commonly used chemotherapy drug.

Chemical Structure and Properties

Carboxyphosphamide has a molecular formula of C7H15Cl2N2O3P and a molecular weight of 279.08 g/mol. It is a white crystalline powder that is soluble in water and alcohol. The chemical structure of carboxyphosphamide includes a phosphoramide group, which is responsible for its alkylating properties.

Mechanism of Action

Carboxyphosphamide, like other alkylating agents, works by interfering with the DNA of cancer cells, preventing them from dividing and growing. It forms covalent bonds with the DNA, causing cross-linking and breakage of the DNA strands. This leads to cell death, particularly in rapidly dividing cells such as cancer cells.

Clinical Uses

Carboxyphosphamide is used in the treatment of various types of cancer, including breast cancer, lung cancer, ovarian cancer, and lymphoma. It is often used in combination with other chemotherapy drugs to increase its effectiveness.

Side Effects

The most common side effects of carboxyphosphamide include nausea, vomiting, hair loss, and fatigue. More serious side effects can include bone marrow suppression, leading to a decrease in white blood cells, red blood cells, and platelets. This can increase the risk of infection, anemia, and bleeding.

Precautions

Patients receiving carboxyphosphamide should be closely monitored for side effects and for signs of infection. Regular blood tests are necessary to monitor blood cell counts. Patients should also be aware of the potential for hair loss and should discuss this with their healthcare provider.

See Also

• Cyclophosphamide
• Chemotherapy
• Alkylating agent