CatSper2

CatSper2 is a protein that in humans is encoded by the CATSPER2 gene. It is a member of the CatSper family of proteins, which are essential for sperm function and fertility in many species.

Function

CatSper2, along with other members of the CatSper family, is involved in the regulation of calcium influx in sperm cells. This calcium influx is necessary for the hyperactivation of sperm, a type of movement that is crucial for successful fertilization.

Structure

The CatSper2 protein is a transmembrane protein, meaning it spans the cell membrane of the sperm cell. It is part of a larger complex of proteins that form a calcium channel in the membrane.

Clinical significance

Mutations in the CATSPER2 gene can lead to infertility in men. This is because these mutations can disrupt the function of the CatSper2 protein, preventing the necessary calcium influx in sperm cells. As a result, the sperm cells may not be able to move in the way that is needed for fertilization.

See also

• CatSper
• Calcium channel
• Infertility