Cdc42 binding protein kinase beta

Cdc42 binding protein kinase beta (CDC42BPA), also known as MRCK beta (Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Beta), is a protein that in humans is encoded by the CDC42BPA gene. This protein is a member of the serine/threonine protein kinase family and is a key regulator of actin cytoskeleton and cell morphology.

Function

The CDC42BPA gene encodes a member of the serine/threonine protein kinase family. This kinase contains a Cdc42/Rac-binding p21 binding domain resembling that of P21-activated kinase (PAK). The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related RhoA-binding kinase (MRCK), both of which belong to the Rho kinase family. This kinase and MRCK are both actin cytoskeletal regulators. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Clinical significance

CDC42BPA has been studied in the context of several diseases, including cancer, diabetes, and neurological disorders. It is thought to play a role in the regulation of cell morphology and cytoskeletal organization.

Interactions

CDC42BPA has been shown to interact with CDC42, a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression.

See also

• Cdc42
• Serine/threonine protein kinase
• Rho kinase

External links

• NCBI Gene
• UniProt