Cefamandole nafate

Cefamandole nafate is a second-generation cephalosporin antibiotic. It is a broad-spectrum antibiotic that is primarily used in the treatment of bacterial infections. Cefamandole nafate is a prodrug that is converted in the body to its active form, cefamandole.

Pharmacology

Cefamandole nafate is a prodrug, which means it is administered in an inactive form and is converted into its active form in the body. The active form of cefamandole nafate, cefamandole, is a bactericidal antibiotic that works by inhibiting the synthesis of the bacterial cell wall. This leads to the death of the bacteria, effectively treating the infection.

Clinical Use

Cefamandole nafate is used in the treatment of a variety of bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, and bone and joint infections. It is also used in the prevention of infections in surgical procedures.

Side Effects

Like all antibiotics, cefamandole nafate can cause side effects. The most common side effects include nausea, vomiting, diarrhea, and rash. In rare cases, cefamandole nafate can cause serious side effects such as anaphylaxis, a severe allergic reaction.

Precautions

Patients with a history of allergy to cephalosporin antibiotics should not take cefamandole nafate. It should also be used with caution in patients with kidney disease, as the drug is primarily excreted by the kidneys.

See Also

• Cephalosporin
• Prodrug
• Bacterial infection