Cenicriviroc
Cenicriviroc[edit | edit source]
Cenicriviroc is a pharmaceutical compound that acts as a dual antagonist of the CCR2 and CCR5 receptors. It is primarily being investigated for its potential use in the treatment of non-alcoholic steatohepatitis (NASH) and other inflammatory conditions.
Mechanism of Action[edit | edit source]
Cenicriviroc functions by blocking the CCR2 and CCR5 receptors, which are involved in the recruitment of monocytes and macrophages to sites of inflammation. By inhibiting these receptors, cenicriviroc reduces the infiltration of inflammatory cells into tissues, thereby potentially alleviating inflammatory conditions such as NASH.
Clinical Development[edit | edit source]
Cenicriviroc has been evaluated in several clinical trials for its efficacy and safety in treating NASH. The drug has shown promise in reducing liver fibrosis and improving liver function in patients with this condition. It is also being studied for its potential benefits in other diseases characterized by chronic inflammation.
Pharmacokinetics[edit | edit source]
Cenicriviroc is administered orally and has a favorable pharmacokinetic profile, with good bioavailability and a long half-life that supports once-daily dosing. The drug is metabolized primarily in the liver and excreted in the feces.
Potential Side Effects[edit | edit source]
As with any medication, cenicriviroc may cause side effects. Commonly reported adverse effects include headache, fatigue, and gastrointestinal disturbances. However, the drug is generally well-tolerated in clinical studies.
Research and Future Directions[edit | edit source]
Ongoing research is focused on further elucidating the therapeutic potential of cenicriviroc in NASH and other inflammatory diseases. Studies are also exploring its use in combination with other agents to enhance its efficacy and broaden its therapeutic applications.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
