From WikiMD's Wellness Encyclopedia


Centanafadine is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that is being investigated for the treatment of attention deficit hyperactivity disorder (ADHD). It is known for its unique pharmacological profile, which involves the inhibition of the reuptake of three key neurotransmitters: serotonin, norepinephrine, and dopamine.

Pharmacology[edit | edit source]

Centanafadine works by inhibiting the reuptake of serotonin, norepinephrine, and dopamine, which increases the levels of these neurotransmitters in the synaptic cleft and enhances neurotransmission. This mechanism is believed to contribute to its therapeutic effects in managing symptoms of ADHD.

Mechanism of Action[edit | edit source]

The drug's mechanism of action involves binding to the transporters responsible for the reuptake of serotonin, norepinephrine, and dopamine. By inhibiting these transporters, centanafadine increases the concentration of these neurotransmitters in the synaptic cleft, thereby enhancing their activity in the brain.

Clinical Trials[edit | edit source]

Centanafadine has undergone several clinical trials to evaluate its efficacy and safety in treating ADHD. These trials have shown promising results, indicating that centanafadine may be an effective treatment option for individuals with ADHD.

Side Effects[edit | edit source]

As with any medication, centanafadine may cause side effects. Common side effects observed in clinical trials include insomnia, dry mouth, headache, and nausea. It is important for patients to discuss potential side effects with their healthcare provider.

Comparison with Other ADHD Medications[edit | edit source]

Centanafadine is distinct from other ADHD medications such as methylphenidate and amphetamine-based treatments due to its triple reuptake inhibition mechanism. This unique profile may offer advantages in terms of efficacy and side effect profile.

Future Directions[edit | edit source]

Ongoing research is focused on further understanding the long-term effects and potential benefits of centanafadine in treating ADHD. Additional studies are needed to fully establish its place in the therapeutic landscape for ADHD.

See Also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD