Centromere protein B

From WikiMD's Wellness Encyclopedia

Centromere protein B (CENP-B) is a protein that in humans is encoded by the CENPB gene. It is a highly conserved DNA-binding protein that is important for the assembly of specific centromere structures.

Function[edit | edit source]

CENP-B is a centromeric autonomously replicating sequence (ARS) binding protein that binds to a specific subset of alphoid DNA, a particular class of centromeric repeats. CENP-B is thought to be involved in the organization of centromeric chromatin and the proper segregation of chromosomes during mitosis and meiosis.

Structure[edit | edit source]

The CENP-B protein contains a DNA-binding domain at its N-terminus, which can bind to the 17 bp CENP-B box sequence present in alphoid DNA repeats. The C-terminal part of the protein is thought to be involved in protein-protein interactions, possibly helping to recruit other proteins to the centromere.

Clinical significance[edit | edit source]

Mutations in the CENPB gene have been associated with various diseases, including autoimmune diseases and certain types of cancer. In addition, abnormal expression of CENP-B has been observed in several types of cancer, suggesting a role in tumorigenesis.

See also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD