Cercopithecine alphaherpesvirus 9

Cercopithecine alphaherpesvirus 9 (CeHV-9) is a species of virus in the genus Simplexvirus, which is part of the subfamily Alphaherpesvirinae within the family Herpesviridae. This virus primarily infects non-human primates, particularly those in the family Cercopithecidae, which includes various species of Old World monkeys.

Virology

CeHV-9 is a double-stranded DNA virus with a genome that is characteristic of the Herpesviridae family. Like other alphaherpesviruses, CeHV-9 is known for its ability to establish latent infections in the host, which can reactivate under certain conditions. The virus is enveloped and has an icosahedral capsid structure.

Pathogenesis

In its natural hosts, CeHV-9 can cause a range of symptoms, from mild to severe. The virus is capable of causing vesicular lesions on the skin and mucous membranes, similar to those caused by other simplexviruses. In some cases, it can lead to more severe systemic infections, particularly in immunocompromised individuals.

Transmission

CeHV-9 is primarily transmitted through direct contact with infected bodily fluids, such as saliva or genital secretions. It can also be spread through aerosol transmission in close quarters, which is a common route of transmission among primate populations.

Diagnosis

Diagnosis of CeHV-9 infection can be achieved through various laboratory techniques, including polymerase chain reaction (PCR) to detect viral DNA, serological tests to identify antibodies against the virus, and virus isolation in cell culture.

Prevention and Control

Preventive measures for CeHV-9 include maintaining good hygiene practices in primate facilities and minimizing direct contact with infected individuals. Vaccination strategies are still under research, and there is currently no specific vaccine available for CeHV-9.

Research and Implications

Research on CeHV-9 is important for understanding the cross-species transmission potential of herpesviruses and their impact on both animal and human health. Studies on CeHV-9 can provide insights into the mechanisms of viral latency, reactivation, and immune evasion.

Also see

• Herpesviridae
• Alphaherpesvirinae
• Simplexvirus
• Viral latency
• Zoonosis