From WikiMD's Wellness Encyclopedia


Cerdulatinib is a small molecule inhibitor of spleen tyrosine kinase (SYK) and Janus kinase (JAK) enzymes. It is being investigated for its potential use in the treatment of various hematologic malignancies and autoimmune diseases.

Mechanism of Action[edit | edit source]

Cerdulatinib functions by inhibiting the activity of both SYK and JAK enzymes. SYK is a key player in the signaling pathways of B cells and other immune cells, while JAK enzymes are involved in the signaling of various cytokines and growth factors. By inhibiting these pathways, cerdulatinib can potentially reduce the proliferation and survival of malignant cells and modulate immune responses.

Clinical Development[edit | edit source]

Cerdulatinib is currently undergoing clinical trials to evaluate its efficacy and safety in patients with different types of lymphoma and leukemia. Early-phase studies have shown promising results, particularly in patients with relapsed or refractory disease.

Potential Indications[edit | edit source]

Cerdulatinib is being explored for use in the treatment of:

Side Effects[edit | edit source]

As with many targeted therapies, cerdulatinib may cause side effects. Commonly reported adverse effects include:

Research and Future Directions[edit | edit source]

Ongoing research aims to better understand the full therapeutic potential of cerdulatinib, including its use in combination with other treatments. Future studies will focus on optimizing dosing regimens and identifying biomarkers that predict response to therapy.

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]



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Contributors: Prab R. Tumpati, MD