Chelerythrine

Chelerythrine is a benzophenanthridine alkaloid that is present in the plant Chelidonium majus (greater celandine). It is a potent, selective, and cell-permeable protein kinase C inhibitor. Chelerythrine has been shown to interact with DNA and RNA, and has been studied for its potential anti-cancer properties.

Chemistry[edit | edit source]

Chelerythrine is a benzophenanthridine alkaloid, a class of compounds that are derived from the isoquinoline alkaloids. It has a planar structure, with a positively charged nitrogen atom that allows it to interact with DNA and RNA.

Biological activity[edit | edit source]

Chelerythrine is a potent inhibitor of protein kinase C, a family of enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues. It is cell-permeable, meaning it can cross cell membranes to exert its effects.

Potential therapeutic uses[edit | edit source]

Chelerythrine has been studied for its potential anti-cancer properties. It has been shown to induce apoptosis, or programmed cell death, in cancer cells. It has also been shown to inhibit the growth of certain types of bacteria and fungi.

Safety[edit | edit source]

While chelerythrine has potential therapeutic uses, it is also toxic. It can cause liver damage, and it is a potent irritant to the eyes and skin.

See also[edit | edit source]

Chelerythrine Resources
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