Chlornaltrexamine

Chlornaltrexamine is a potent opioid antagonist used in scientific research. It is derived from naltrexone and is approximately 10 times more potent. Chlornaltrexamine is an irreversible opioid antagonist, meaning it permanently binds to the opioid receptors, preventing any subsequent effects from opioids.

Chemistry

Chlornaltrexamine is a derivative of naltrexone, which is itself a derivative of oxymorphone. The chemical structure of chlornaltrexamine includes a chlorine atom, which is responsible for its increased potency and irreversible binding to the opioid receptors.

Pharmacology

Chlornaltrexamine acts as an antagonist at the mu-opioid receptor, kappa-opioid receptor, and delta-opioid receptor. It has a high affinity for these receptors and binds irreversibly, blocking the effects of opioids for an extended period of time. This makes chlornaltrexamine a useful tool in research for studying the effects of opioid antagonism.

Uses

Chlornaltrexamine is primarily used in scientific research. It is used to study the effects of opioid antagonism and to develop new treatments for opioid addiction and overdose. Due to its irreversible binding, it can provide a long-lasting blockade of opioid effects, which is useful in studying the long-term effects of opioid antagonism.

Side Effects

As an opioid antagonist, chlornaltrexamine can precipitate withdrawal symptoms in individuals who are physically dependent on opioids. Other potential side effects include pain at the injection site, nausea, and vomiting.

See Also

• Naltrexone
• Opioid antagonist
• Opioid receptor