Cholecystokinin A receptor
Cholecystokinin A Receptor[edit | edit source]
The cholecystokinin A receptor (CCKAR), also known as the CCK1 receptor, is a G protein-coupled receptor that binds the peptide hormone cholecystokinin (CCK). This receptor is primarily found in the gastrointestinal tract and the central nervous system, where it plays a crucial role in digestion and appetite regulation.
Structure[edit | edit source]
The CCKA receptor is a member of the G protein-coupled receptor (GPCR) family, characterized by its seven transmembrane alpha-helices. The receptor's structure allows it to interact with G proteins, which are intracellular proteins that transmit signals from the receptor to various signaling pathways within the cell.
Function[edit | edit source]
The primary function of the CCKA receptor is to mediate the effects of cholecystokinin in the body. When CCK binds to the CCKA receptor, it triggers a cascade of intracellular events that lead to the secretion of digestive enzymes from the pancreas and the release of bile from the gallbladder. This process is essential for the digestion of fats and proteins.
In addition to its role in digestion, the CCKA receptor is involved in regulating satiety and appetite. Activation of the receptor in the brain can lead to a feeling of fullness, thereby reducing food intake.
Distribution[edit | edit source]
The CCKA receptor is predominantly expressed in the gastrointestinal tract, particularly in the pancreas, gallbladder, and small intestine. It is also found in the central nervous system, including areas of the brain involved in appetite control.
Clinical Significance[edit | edit source]
Alterations in CCKA receptor function or expression can have significant clinical implications. Dysregulation of this receptor has been associated with obesity, pancreatitis, and gallstone formation. Understanding the role of the CCKA receptor in these conditions can help in developing targeted therapies.
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