Cholecystokinin A receptor

Cholecystokinin A receptor (CCKAR) is a protein that in humans is encoded by the CCKAR gene. It is a type of G protein-coupled receptor that binds cholecystokinin (CCK), a hormone that aids in the process of digestion.

Function

The Cholecystokinin A receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the brain, its function is unclear, but it is thought to be involved in satiety and anxiety. It is located in the gastrointestinal tract and the central nervous system.

Structure

The CCKAR protein is a member of the G protein-coupled receptor family. It is a transmembrane receptor that is activated by the binding of cholecystokinin (CCK). The receptor is coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system.

Clinical significance

Alterations in the function of the Cholecystokinin A receptor have been associated with various diseases, including pancreatitis, gallstones, and certain types of cancer. In addition, it has been suggested that the receptor may play a role in anxiety disorders and eating disorders.

See also

• Cholecystokinin B receptor
• G protein-coupled receptor
• Cholecystokinin

References

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