Cholestatic pruritus

Cholestatic pruritus is a condition characterized by severe itching as a result of cholestasis, a condition where bile cannot flow from the liver to the duodenum. The pruritus, or itch, associated with cholestatic pruritus can be severe and may cause significant discomfort and distress.

Causes

Cholestatic pruritus is caused by cholestasis, a condition where bile, a substance produced by the liver to help digest fats, cannot flow from the liver to the duodenum. This can be due to a blockage in the bile ducts or a problem with the liver itself. Conditions that can cause cholestasis and subsequently cholestatic pruritus include primary biliary cirrhosis, primary sclerosing cholangitis, and certain medications.

Symptoms

The primary symptom of cholestatic pruritus is severe itching, which can be generalized or localized. Other symptoms can include jaundice, dark urine, pale stools, and fatigue.

Diagnosis

Diagnosis of cholestatic pruritus involves a thorough medical history and physical examination, as well as blood tests to check liver function and imaging studies to look for blockages in the bile ducts.

Treatment

Treatment for cholestatic pruritus focuses on addressing the underlying cause of the cholestasis. This can involve medication to improve bile flow, treating the underlying liver disease, or in some cases, surgery to relieve a blocked bile duct.

See also

• Cholestasis
• Pruritus
• Liver disease
• Bile duct

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