Chromatin target of prmt1
Chromatin target of PRMT1 (also known as Chtop) is a protein that in humans is encoded by the CHTOP gene. This protein is a component of the chromatin and plays a crucial role in the regulation of gene expression.
Function[edit | edit source]
The Chtop protein is a component of the mRNA export complex, which is involved in the nuclear export of fully processed mRNA molecules. It is also a part of the TREX (Transcription Export) complex, which is involved in coupling transcription and mRNA export.
Chtop is a target of PRMT1 (Protein Arginine Methyltransferase 1), an enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.
Clinical significance[edit | edit source]
Alterations in the function of Chtop and PRMT1 have been associated with several diseases, including cancer, cardiovascular disease, and neurodegenerative disease.
See also[edit | edit source]
References[edit | edit source]
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