Chromatin target of prmt1

Chromatin target of PRMT1 (also known as Chtop) is a protein that in humans is encoded by the CHTOP gene. This protein is a component of the chromatin and plays a crucial role in the regulation of gene expression.

Function

The Chtop protein is a component of the mRNA export complex, which is involved in the nuclear export of fully processed mRNA molecules. It is also a part of the TREX (Transcription Export) complex, which is involved in coupling transcription and mRNA export.

Chtop is a target of PRMT1 (Protein Arginine Methyltransferase 1), an enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.

Clinical significance

Alterations in the function of Chtop and PRMT1 have been associated with several diseases, including cancer, cardiovascular disease, and neurodegenerative disease.

See also

• Chromatin
• PRMT1
• Gene expression
• mRNA
• Transcription
• TREX complex